Would I be SOL trying to get a Ryzen/Nvidia Hackinthosh going?

CPU: Ryzen 9 5950X
GPU: Gigabyte Aorus Xtream Waterforce RTX 4080
RAM: Corsair Vengeance RGB Pro (32 GB) (DDR4-3600 CL18)
Motherboard/Laptop Make and Model: Asus ROG Crosshair VIII Hero
Audio Codec:
ROG SupremeFX8-Channel High Definition Audio CODEC
Ethernet Card:

Realtek® RTL8125-CG 2.5G LAN

ROG GameFirst Technology

Intel® I211-AT

ASUS LAN Guard
Wifi/BT Card: GIGABYTE Bluetooth 4.0 and WiFi Card

1. Wi-Fi 802.11 b/g/n
2. Bluetooth 4.0, 3.0+HS, 2.1+EDR
   Touchpad and touch display devices:
   BIOS revision: 4201