Compatibility of Current Desktop?

Edit: a word

Hey everyone, I have a desktop I built about a year ago, and am wondering how compatible it would be with MacOS Sierra (or High Sierra).

The main specs are:

Motherboard: MSI H110M ECO (https://www.newegg.com/Product/Product.aspx?Item=N82E16813130910)

CPU: Intel i3-6100 (Skylake) (https://www.newegg.com/Product/Product.aspx?Item=2MN-0004-00002)

GPU: AMD Radeon RX 470 (N/A) Wireless card: TP-Link AC1900 (https://www.amazon.com/gp/product/B00TQEX7AQ/ref=oh_aui_detailpage_o02_s00?ie=UTF8&psc=1)

I've done some research, and it appears that the Motherboard and CPU are supported out of the box, but the graphics card had mixed results.

Dumb question, but if it all is compatible, do I just follow the Vanilla guide in the sidebar? Would I need any special kexts not mentioned, especially for the graphics card?

Thanks!